A dichlorination-reductive-dechlorination route to N-acetyl-2-oxazolone
FC Gaenzler, MB Smith
Index: Gaenzler, Faith Corbo; Smith, Michael B. Synlett, 2007 , # 8 p. 1299 - 1301
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Citation Number: 4
Abstract
Abstract We have shown that sulfuryl chloride is an efficient reagent for the conversion of 2- oxazolidinone into the dichloro derivative, N-acetyl-4, 5-dichloro-2-oxazolidinone. Subsequent Zn/AcOH reductive dehalogenation of this trans-dichloride gives N-acetyl-2- oxazolone. The dichloride was previously reported as an undesired side product in the preparation of N-acetyl-2-oxazolone from the monochloro oxazolidinone. In our hands, the ...
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