Thermal solvent-free synthesis of novel pyrazolyl chalcones and pyrazolines as potential antimicrobial agents
ZN Siddiqui, TNM Musthafa, A Ahmad…
Index: Siddiqui, Zeba N.; Mohammed Musthafa; Ahmad, Anis; Khan, Asad U. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 10 p. 2860 - 2865
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Citation Number: 62
Abstract
Abstract A novel approach was adopted for the synthesis of series of new pyrazolyl chalcones (3a–c) by the reaction of 5-chloro-3-methyl-1-phenylpyrazole-4-carboxaldehyde (1) with different 5-acetylbarbituric acid derivatives (2a–c) under thermal solvent-free condition. The chalcones were then converted to the corresponding pyrazolines (4a–c) under the same condition in excellent yields. All the synthesized compounds were ...
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