" Mediator methodology" for the synthesis of peptides in a two-polymeric system

Y Shai, KA Jacobson, A Patchornik

Index: Shai, Yechiel; Jacobson, Kenneth A.; Patchornik, Abraham Journal of the American Chemical Society, 1985 , vol. 107, # 14 p. 4249 - 4252

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Citation Number: 40

Abstract

Abstract: A novel methodology is described for a potential automated self-controlled synthesis of peptides. The method is based on transferring an N-protected amino acid from one insoluble polymer (donor) such as a polymeric o-nitrophenyl ester (a “bank” of active ester) to an insoluble polymer-bound amino acid (acceptor), with the aid of a soluble mediator molecule (shadchan). 2 The method gives high yields of pure peptides by ...