Small molecule inhibitors of Myc/Max dimerization and Myc-induced cell transformation

…, JS Stover, LR Whitby, PK Vogt, DL Boger

Index: Shi, Jin; Stover, James S.; Whitby, Landon R.; Vogt, Peter K.; Boger, Dale L. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 21 p. 6038 - 6041

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Citation Number: 37

Abstract

The c-myc proto-oncogene is involved in the progression of a wide range of human tumors. 1, 2, 3, 4 and 5 Proteins in the immediate Myc network are essential regulators of differentiation and proliferation. Oncogenic transformation occurs mainly through elevated expression of its gene product Myc, a short-lived nuclear protein and an important member of the basic helix–loop–helix leucine zipper (bHLHLZ) transcription factors (Fig. 1). 6 The oncogenic ...