Free-radical addition of 1-thiosugars to alkenes a new general approach to the synthesis of 1-thioglycosides

JM Lacombe, N Rakotomanomana, AA Pavia

Index: Lacombe, J. M.; Rakotomanomana, N.; Pavia, A. A. Tetrahedron Letters, 1988 , vol. 29, # 34 p. 4293 - 4296

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Citation Number: 23

Abstract

Summary : Addition of peracetylated 1-thiosugars to alkenes in the presence of azobis(isobutyronihile) (AIBN) as initiator constitutes an efficient route to alkyl 1-thioglycosides as well as to 1-thioglycosides bearing a reactive group on the aglycon. ... We have recently reported the preparation of macromolecular conjugates suitable for the study of various biological phenomena including affinity-labeling of cell &tins, by telomerization of unsaturated monomers ...