Insulin secretion-stimulating activity of certain derivatives of the C-terminal tetrapeptide of cholecystokinin

…, YP Shvachkin, AA Shishkina, LA Kolomeitseva

Index: Sadovnikova, N. V.; Fedotov, V. P.; Shvachkin, Yu. P.; Shishkina, A. A.; Kolomeitseva, L. A. Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 12 p. 838 - 842 Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 12 p. 1424 - 1427

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Abstract

(X) __. _ u. The amide X was synthesized analogously to compound V from 0.3 g (0.0006 mole) of the pentafluorophenyl ester of di-tert-butyloxycarbonyl-L-ornithine, 0.08 ml (0.0006 mole) triethylamine, and 0.32 g (0~ mole) of the tripeptide trifluoroacetate VIII. After evaporation of the reaction mixture, the residue was dissolved in an ethyl acetate-water mixture, i: io The organic layer was removed and washed with a 5% solution of KHSO~, ...