Multistep Continuous??Flow Synthesis in Medicinal Chemistry: Discovery and Preliminary Structure–Activity Relationships of CCR8 Ligands

TP Petersen, S Mirsharghi, PC Rummel…

Index: Petersen, Trine P.; Mirsharghi, Sahar; Rummel, Pia C.; Thiele, Stefanie; Rosenkilde, Mette M.; Ritzen, Andreas; Ulven, Trond Chemistry - A European Journal, 2013 , vol. 19, # 28 p. 9343 - 9350

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Citation Number: 10

Abstract

Abstract A three-step continuous-flow synthesis system and its application to the assembly of a new series of chemokine receptor ligands directly from commercial building blocks is reported. No scavenger columns or solvent switches are necessary to recover the desired test compounds, which were obtained in overall yields of 49–94%. The system is modular and flexible, and the individual steps of the sequence can be interchanged with similar ...