Design, synthesis and biological evaluation of novel pyrimidine, 3-cyanopyridine and m-amino-N-phenylbenzamide based monocyclic EGFR tyrosine kinase …
Y Mao, W Zhu, X Kong, Z Wang, H Xie, J Ding…
Index: Mao, Yongjun; Zhu, Wenxiu; Kong, Xiaoguang; Wang, Zhen; Xie, Hua; Ding, Jian; Terrett, Nicholas Kenneth; Shen, Jingkang Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 11 p. 3090 - 3104
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Citation Number: 13
Abstract
36 new compounds with the typical skeleton of 4-anilino-5-vinyl/ethynyl pyrimidine, 4-anilino- 3-cyano-5-vinyl/ethynyl/phenyl pyridine, and m-amino-N-phenylbenzamide, are designed, synthesized and selectively tested on EGFR, ErbB-2 kinases, and A-549, HL60 cells growth inhibition. Results from the bioactivity and chemical structures yield preliminary structure– activity relationships (SARs). The most potent 5-ethynylpyrimidine derivative 20a has an ...
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