Reduction of peptide character of HIV protease inhibitors that exhibit nanomolar potency against multidrug resistant HIV-1 strains
H Tamamura, Y Koh, S Ueda, Y Sasaki…
Index: Sham, Hing L.; Betebenner, David A.; Zhao, Chen; Wideburg, Norman E.; Saldivar, Ayda; et al. Journal of the Chemical Society, Chemical Communications, 1993 , # 13 p. 1052 - 1053
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Citation Number: 43
Abstract
... synthesized using the (d-Ser, l-Phe)-type EADI [Cbz-d-Ser-ψ[(E)-CH CH]-l-Phe-OBu t ... bond at the P 1 −P 2 position of compound 14 was replaced by an (E)-alkene, and ... in 1,4-dioxane; (v) MsCl, DIPEA; (vi) NaIO 4 ; (vii) isobutylamine; (viii) p-nitrobenzenesulfonyl chloride, Et 3 N ...
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