An efficient, palladium-catalyzed route to protected allylic amines

…, T Rein, B Aakermark, P Helquist

Index: Connell, Richard D.; Rein, Tobias; Akermark, Bjoern; Helquist, Paul Journal of Organic Chemistry, 1988 , vol. 53, # 16 p. 3845 - 3849

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Citation Number: 105

Abstract

5 6 version of allylic acetates and chlorides to the corresponding amines. Phthalimide, 5 sodium azide! p-toluenesulfonamide, 7 and 4, 4'-dimeth~ xybenzhydrylamine~ have been shown to be useful nucleophiles in these reactions. Although the intermediates formed from these reactions can then be converted to the amine, the conditions for this transformation are often quite harsh. For example, phthalimides are often removed by hydrazine in refluxing ...