Asymmetric reduction of aliphatic. delta.-keto acids with sodium borohydride in the presence of bovine serum albumin
M Utaka, H Watabu, A Takeda
Index: Utaka, Masanori; Watabu, Hisashi; Takeda, Akira Journal of Organic Chemistry, 1986 , vol. 51, # 26 p. 5423 - 5425
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Citation Number: 8
Abstract
The asymmetric reduction of the prochiral carbonyl group of 6-keto acids attracts interest because it is a key step for the facile synthesis of optically active &lactones. The asymmetric reduction of prochiral ketones has been studied extensively,'and considerable success has been attained especially for aromatic or a, &unsaturated ketones with high optical yields of more than 90% ee. 2 In contrast, aliphatic ketones have generally been reduced with ...
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