Quaternary Carbon Compounds. I. Trialkylacetic Acids as Antispasmodic Agents1

N Sperber, D Papa, E Schwenk

Index: Sperber; Papa; Schwenk Journal of the American Chemical Society, 1948 , vol. 70, p. 3092

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Citation Number: 36

Abstract

I I1 antispasmodic activity is exhibited by those compounds wherein li, R'and R" are three, four or five carbon alkyl groups and total 12-17 carbon atoms. In contrast, trialkylacetamides having 7-11 carbon atoms show only weak antispasmodic a~ tivity.~ However, the latter substances are potent soporifics, a type of action not shown by the higher homologous compounds even in large doses. In view of the accessibility of the trialkylacetamides, it ...