Tetrahedron letters

A convergent synthesis of Ro24-5913, a novel leukotriene D 4 antagonist

H Maehr, R Yang

Index: Maehr, Hubert; Yang, Roxana Tetrahedron Letters, 1996 , vol. 37, # 31 p. 5445 - 5448

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Citation Number: 13

Abstract

A new and convergent synthesis of the leukotriene D4 antagonist Ro24-5913 (9) has been developed that can serve both for technical production and combinatorial strcture optimization. The synthesis of 6, achieved in 90% yield, is described. The conversion of 6 to 9 has been disclosed previously.