The preparation of 3 H-labeled acyclic nucleoside phosphonates and study of their stability
T Elbert, P Břehová, A Holý
Index: Elbert, Tomas; Brehova, Petra; Holy, Antonin Collection of Czechoslovak Chemical Communications, 2010 , vol. 75, # 7 p. 757 - 766
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Citation Number: 3
Abstract
Abstract 9-(2-Phosphonomethoxyethyl)-2, 6-diamino-[8-3 H] purine (4), 9-(2- phosphonomethoxyethyl)-[8-3 H] guanine (6) and (R)-9-(2-phosphonomethoxypropyl)-[8-3 H] adenine (11) with specific activities of 10.9, 7.9 and 16 Ci/mmol, respectively, were prepared by a catalytic dehalogenation of the corresponding 8-bromo derivatives 1, 2 and 9. The rate of the exchange of the tritium label on C-8 of the purine ring in title compounds ...
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