A short and concise asymmetric synthesis of hamigeran B

BM Trost, C Pissot??Soldermann…

Index: Trost, Barry M.; Pissot-Soldermann, Carole; Chen, Irwin Chemistry - A European Journal, 2005 , vol. 11, # 3 p. 951 - 959

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Citation Number: 36

Abstract

Abstract The interesting biological properties of the hamigerans wherein hamigeran B is a potent antiviral agent with low cytotoxicity to host cells make these deceptively simple looking structures challenging synthetic targets. A strategy to hamigeran B evolved wherein the three contiguous stereocenters are established ultimately from a Pd catalyzed asymmetric allylic alkylation (AAA). The latter involves an asymmetric allylation of a non- ...

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