A General Palladium??Catalyzed Carbonylative Synthesis of Chromenones from Salicylic Aldehydes and Benzyl Chlorides

XF Wu, L Wu, R Jackstell, H Neumann…

Index: Wu, Xiao-Feng; Wu, Lipeng; Jackstell, Ralf; Neumann, Helfried; Beller, Matthias Chemistry - A European Journal, 2013 , vol. 19, # 37 p. 12245 - 12248

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Abstract

Chromenones (3-aryl-2H-chromen-2-one) is an important scaffold found in many natural products and synthetic drugs or drug candidates exhibiting a wide range of biological activities, including anticancer, antioxidant, and anti-HIV activities, as well as acting as enzymatic inhibitors (Scheme 1).[1] In addition, applications in the perfume industry and advanced materials have been described.[2] As a result, considerable synthetic effort has ...