The Journal of Organic Chemistry

Synthesis of isoquinolines from indenes

RB Miller, JM Frincke

Index: Miller, R. Bryan; Frincke, James M. Journal of Organic Chemistry, 1980 , vol. 45, # 26 p. 5312 - 5315

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Citation Number: 49

Abstract

3 NH4OH be complete. In a similar manner and with an arbitrary reduction time of 11 h, the resulting crude solution of homophthalaldehyde was treated with aqueous ammonium hydroxide (30 equiv), After 5 h, amination was found to be essentially complete. When these conditions were applied to the conversion of indene to isoquinoline, consistent isolated yields of 73-82% were obtained. Other variants in the reaction condit, ions such as ...