Synthesis of 1-deoxynojirimycin and N-butyl-1-deoxynojirimycin
CRR Matos, RSC Lopes, CC Lopes
Index: Matos, Carlos R. R.; Lopes, Rosangela S. C.; Lopes, Claudio C. Synthesis, 1999 , # 4 p. 571 - 573
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Citation Number: 32
Abstract
Abstract: 1-Deoxynojirimycin (1) is a natural alkaloid with several biological activities; the analog N-butyl-1-deoxynojirimycin (4), for example has shown potent anti HIV-1 and HIV-2 activity without cytotoxicity. As part of a program to synthesize compounds with biological activity against retroviruses, we developed an efficient route for the preparation of 1 and 4 employing as raw material glucose and others inexpensive reagents. Key words: alkaloids ...
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