Chemical Communications

A Ramberg–Bäcklund route to the stilbenoid anti-cancer agents combretastatin A-4 and DMU-212

JE Robinson, RJK Taylor

Index: Robinson, James E.; Taylor, Richard J. K. Chemical Communications, 2007 , # 16 p. 1617 - 1619

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Citation Number: 20

Abstract

A concise route to combretastatin A-4, a potent inhibitor of tubulin polymerisation, using a Ramberg–Bäcklund reaction to form the key (Z)-stilbene unit has been developed; this Ramberg–Bäcklund approach has also been extended to prepare the (E)-stilbene DMU- 212, which also possesses interesting growth inhibitory properties.