A process for the rapid removal of dialkylamino-substituents from aromatic rings. Application to the expedient synthesis of (R)-tolterodine
NA Paras, B Simmons, DWC MacMillan
Index: Paras, Nick A.; Simmons, Bryon; MacMillan, David W.C. Tetrahedron, 2009 , vol. 65, # 16 p. 3232 - 3238
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Citation Number: 25
Abstract
A range of N, N-dialkylanilines have been successfully converted to the parent substituted benzenes by a novel two-step pathway. The products are obtained in good yields and optical purity of adjacent stereocenters is maintained. This technology has been applied toward the synthesis of (R)-tolterodine.
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