Tetrahedron Letters

Efficient synthesis of protected 3′-deoxyadenosine and 3′-deoxyguanosine from adenosine and guanosine

Z Cui, L Zhang, B Zhang

Index: Cui, Zhiyong; Zhang, Lei; Zhang, Biliang Tetrahedron Letters, 2001 , vol. 42, # 4 p. 561 - 563

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Citation Number: 10

Abstract

Highly efficient synthesis of protected 3′-deoxyadenosine and 3′-deoxyguanosine from adenosine and guanosine were described. The 2′, 3′-diol of protected adenosine and guanosine were reacted with α-acetoxyisobutyryl bromide to yield 9-(2′-O-acetyl-3′- bromo-5′-O-tert-butyldiphenylsilyl-3′-deoxy-β-d-xylofuranosyl)-6-N-benzoyl adenine and 9-(2′-O-acetyl-3′-bromo-5′-O-tert-butyldiphenylsilyl-3′-deoxy-β-d-xylofuranosyl)-2-N ...

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