Synthesis and preliminary evaluation of benzimidazole derivatives as antimicrobial agents

…, M Pour, J Stachel, K Waisser, J Kaustová

Index: Klimesova, Vera; Koci, Jan; Pour, Milan; Stachel, Jiri; Waisser, Karel; Kaustova, Jarmila European Journal of Medicinal Chemistry, 2002 , vol. 37, # 5 p. 409 - 418

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Citation Number: 102

Abstract

A series of 2-alkylsulphanylbenzimidazoles was synthesised and the compounds were evaluated for their in vitro antimicrobial activity. The structures of the compounds were confirmed by 1H-NMR and IR data, and their purity by elemental analysis. Antimycobacterial activities against Mycobacterium tuberculosis and non-tuberculous mycobacteria as well as antifungal activities against Candida albicans, Candida tropicalis, Candida krusei, ...