Synthesis and biological evaluation of novel neamine–nucleoside conjugates potentially targeting to RNAs

Y Xu, H Jin, Z Yang, L Zhang, L Zhang

Index: Xu, Yanli; Jin, Hongwei; Yang, Zhenjun; Zhang, Liangren; Zhang, Lihe Tetrahedron, 2009 , vol. 65, # 27 p. 5228 - 5239

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Citation Number: 17

Abstract

Eighteen novel neamine–nucleoside conjugates with ethylenediamine–lysine or ethylenediamine–arginine as the linker were synthesized and their potential binding to A site of 16S RNA and TAR RNA was evaluated using SPR (surface plasmon resonance). Compared with neamine, compounds 10i and 10q show 6.3 and 4.8 times potential in binding to A site of 16S RNA and eight and six times potential in binding to TAR RNA, ...