Semisynthetic cephalosporines. Synthesis of some substituted tetrazolyl acetic and propionic acids

Ľ Janda, Z Votický, J Jakubcová, J Světlík…

Index: Janda; Voticky; Jakubcova; et al. Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 7 p. 1699 - 1712

Full Text: HTML

Citation Number: 1

Abstract

Abstract The N-alkylation of 5-[5-(substituted phenyl)-2-furyl]-1H-tetrazoles with ethyl bromoacetate or ethyl 3-bromopropionate afforded a mixture of 5-substituted ethyl 1-and 2- tetrazoyl acetates or propionates, which were separated and hydrolyzed to the corresponding 1-and 2-acetic or propionic acids, and used as intermediates for the synthesis of semisynthetic cephalosporine antibiotics. The prepared tetrazolyl acetic acids ...