Syntheses and antitumor activities of d-and l-2′-deoxy-4′-thio pyrimidine nucleosides

J Uenishi, K Takahashi, M Motoyama…

Index: Uenishi; Takahashi; Motoyama; Akashi; Sasaki Nucleosides and Nucleotides, 1994 , vol. 13, # 6-7 p. 1347 - 1361

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Citation Number: 45

Abstract

Abstract Both enantiomers of 2′-deoxy-4′-thiouridine (9) and 15, 4′-thiothymidine (10) and 16, and 2′-deoxy-4′-thiocytidine (14) and 17 and 1-(2-deoxy-4-thio-β-D-erythro- pentafuranosyl)-5-trifluoromethyluracil (11) were synthesized. The key coupling reactions were performed by the reaction of D-or L-enantiomers of ethyl 5-O-acetyl-3-O-(tert- butyldimethylsilyl)-2-deoxy-4-thio-α, β3-xylofuranoside (1)) or 18 and 2, 4-bis ( ...