Reductive N-monoalkylation of primary aromatic amines
G Verardo, AG Giumanini, P Strazzolini, M Poiana
Index: Verardo; Giumanini; Strazzolini; Poiana Synthesis, 1993 , # 1 p. 121 - 125
Full Text: HTML
Citation Number: 59
Abstract
Primary aromatic amines 1 with a variety of ring substituents are easily converted to their N- monoalkyl derivatives 3 by a simple variation of the sodium borohydride/sulfuric acid/carbonyl compound procedure previously described for their N-perrnethylations. The procedure is suitable for the or-monodeuterium labelling of the new N-substituent.
Related Articles:
[Narasimhan; Balakumar Synthetic Communications, 2000 , vol. 30, # 23 p. 4387 - 4395]
Highly chemoselective nitration of aromatic amines using the Ph 3 P/Br 2/AgNO 3 system
[Tetrahedron Letters, , vol. 47, # 38 p. 6879 - 6881]
[Lemonnier, Jean-Francois; Guenee, Laure; Beuchat, Cesar; Wesolowski, Tomasz A.; Mukherjee, Prasun; Waldeck, David H.; Gogick, Kristy A.; Petoud, Stephane; Piguet, Claude Journal of the American Chemical Society, 2011 , vol. 133, # 40 p. 16219 - 16234]
The mechanism of N-alkylation of weak NH-acids by phase transfer catalysis
[Dehmlow, Eckehard V.; Thieser, Rainer; Zahalka, Hayder Ali; Sasson, Yoel Tetrahedron Letters, 1985 , vol. 26, # 3 p. 297 - 300]
Lead identification of 2-iminobenzimidazole antagonists of the chemokine receptor CXCR3
[Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 7 p. 2414 - 2419]