Novel sulfonylurea derivatives as H 3 receptor antagonists. Preliminary SAR studies

J Ceras, N Cirauqui, S Pérez-Silanes, I Aldana…

Index: Ceras, Javier; Cirauqui, Nuria; Perez-Silanes, Silvia; Aldana, Ignacio; Monge, Antonio; Galiano, Silvia European Journal of Medicinal Chemistry, 2012 , vol. 52, p. 1 - 13

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Citation Number: 13

Abstract

The combination of antagonism at histamine H3 receptor and the stimulation of insulin secretion have been proposed as an approach to new dual therapeutic agents for the treatment of type 2 diabetes mellitus associated with obesity. We have designed and synthesized a new series of non-imidazole derivatives, based on a basic amine ring connected through an alkyl spacer of variable length to a phenoxysulfonylurea moiety. ...