Organic letters

Highly enantioselective and organocatalytic α-amination of 2-oxindoles

L Cheng, L Liu, D Wang, YJ Chen

Index: Cheng, Liang; Liu, Li; Wang, Dong; Chen, Yong-Jun Organic Letters, 2009 , vol. 11, # 17 p. 3874 - 3877

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Citation Number: 131

Abstract

An effective method for the asymmetric synthesis of 3-amino-2-oxindoles was developed. The tetrasubstituted chiral carbon center was generated by asymmetric amination of N- unprotected 2-oxindoles with azodicarboxylate catalyzed by commercial biscinchona alkaloids in good to excellent yields with high enantioselectivities.