Tetrahedron Letters

Microwave assisted catalyst-free synthesis of azaarene-substituted 3-hydroxy-2-oxindoles by the functionalization of sp 3 C–H bond in methyl pyridine

HM Meshram, NN Rao, LC Rao, NS Kumar

Index: Meshram; Nageswara Rao; Chandrasekhara Rao; Satish Kumar Tetrahedron Letters, 2012 , vol. 53, # 31 p. 3963 - 3966

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Citation Number: 44

Abstract

A highly efficient synthesis of azaarene-substituted 3-hydroxy-2-oxindoles in catalyst-free conditions is described by the reaction of 2-methyl pyridines with isatins under microwave irradiation in aqueous medium. Simple reaction conditions, high yields of the products and environmentally benign medium are attractive features of the present protocol.