Synthesis of N-Free 4-Hydroxy-2-thiazoline as an Intermediate in the Hantzsch Thiazole Synthesis

K ARAKAWA, T MIYASAKA…

Index: Arakawa,K. et al. Chemical and Pharmaceutical Bulletin, 1972 , vol. 20, p. 1041 - 1046

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Citation Number: 14

Abstract

4-Hydroxy-2-thiazolines were prepared by interrupting the Hantsch thiazole synthesis at the stage of cyclization. The chemical behavior of the tertiary amines, as well as the AB-quartet pattern at around 3.5 ppm in the NMR spectra, supported the cyclic structure (VII). Thioliminoester structure (VIIIa) proposed by M. Steude was unambiguously denied by the present paper.