Canadian Journal of Chemistry

Reactions of phenyl (trichloromethyl) carbinol with substituted thioureas, thiobenzhydrazide, and amino thiols to form heterocyclic compounds1

W Reeve, WR Coley III

Index: Reeve,W.; Coley,W.R. Canadian Journal of Chemistry, 1979 , vol. 57, p. 444 - 449

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Citation Number: 12

Abstract

Phenyl (trichloromethyl) carbinol reacts with bifunctional reagents containing nucleophilic sulfur such as thioureas, thiobenzhydrazide, o-aminothiophenol, etc., in a series of steps involving an initial attack of the sulfur anion on the intermediate epoxide 2 followed by ring closure to a heterocyclic compound. Thiazolidinones, thiadiazinones, benzothiazinones, and thiomorpholinones are easily obtained in yields ranging from 57-20%. ...

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