Accelerating effect of meta substituents in the ester-mediated nucleophilic aromatic substitution reaction

…, A Takeda, K Suzuki, N Koike, E Koshiishi…

Index: Hattori, Tetsutaro; Takeda, Ayanobu; Suzuki, Kenji; Koike, Nobuyuki; Koshiishi, Eiji; Miyano, Sotaro Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 22 p. 3661 - 3671

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Citation Number: 16

Abstract

The ester-mediated nucleophilic aromatic substitution (SAr) reaction of 2-methoxybenzoic ester 1 with Grignard reagents 11 is greatly accelerated by introduction of a methoxy or halo substituent at the 3-position of the benzoate ring (7–10). The substituent effects of these groups at the 3-position are compared wit