Asymmetric Total Synthesis of Taxol\ R
T Mukaiyama, I Shiina, H Iwadare…
Index: Shiina, Isamu; Iwadare, Hayato; Sakoh, Hiroki; Hasegawa, Masatoshi; Tani, Yu-Ichirou; Mukaiyama, Teruaki Chemistry Letters, 1998 , # 1 p. 1 - 2
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Citation Number: 263
Abstract
Abstract A new method for the total asymmetric synthesis of antitumor agent Taxol is described. Baccatin III, a complex carbon framework, is synthesized by way of B to BC to ABC ring construction. Further, a method of forming Taxol from baccatin III and a β-amino acid is also demonstrated.
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