Studies on anticoccidial agents. 13. Synthesis and anticoccidial activity of nitropyridine-2-and-3-sulfonamides and derivatives

Y Morisawa, M Kataoka, H Nagahori…

Index: Morisawa, Yasuhiro; Kataoka, Mitsuru; Nagahori, Hitoshi; Sakamoto, Toshiaki; Kitano, Noritoshi; et al. Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1376 - 1380

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Citation Number: 19

Abstract

Caldwell et a1. 2 reported that oxidation of 2-mercapto-5-nitropyridine (la) with chlorine resulted in formation of 2-chloro-5-nitropyridine. However, if one applies the modified oxidation of Comrie et al. 3 and amidation, the 2-mercapto derivative la could be converted to 5-nitropyridine-2-sulfonamide (3a), together with the disulfide 2a (Scheme I). A similar transformation has been effected in the synthesis of 3-nitropyridine-2-sulfonamide (3b), ...