The discovery of N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl) oxy] ethoxy]-4-pyrimidinyl]-N′-propylsulfamide (Macitentan), an orally active, potent dual …

…, P Hess, M Iglarz, S Meyer, J Rein, M Rey…

Index: Maggiali, C.; Morini, Giovanni; Mossini, F.; Morini, Giuseppina; Barocelli, E.; Impicciatore, M. Farmaco, Edizione Scientifica, 1988 , vol. 43, # 3 p. 277 - 292

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Citation Number: 115

Abstract

... E-mail: martin.bolli@actelion.com. ... to a solution of 1 equiv of the respective amine (eg, n-propylamine) in the presence of 3 equiv of triethylamine in dichloromethane at 0 °C. The mixture ... This material was dissolved in approximately 5 M HCl in dioxane to affect BOC-deprotection ...