Homotransmetallation des halogeno-3 pyridines bromees en-2 ou-4 par le n-butyllithium. proposition d'un nouveau mecanisme de telesubstitution du brome

M Mallet, G Quéguiner

Index: Mallet, M.; Queguiner, G. Tetrahedron, 1986 , vol. 42, # 8 p. 2253 - 2262

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Citation Number: 24

Abstract

These are new examples of the homotransmetalation reaction. Instead of the ordinary bromo- metal exchange it is possible to obtain selectively from the 2-bromo 3-fluoro or 2-bromo 3- chloro pyridines the 2-bromo 3-halogeno 4-lithio pyridines, which is very interesting for synthetic utility. From the 4-bromo 3-halogeno pyridines, we can see an isomerization with an halogen dance mechanism and we obtain the 5-bromo 3-halogeno 4-lithio pyridines. ...