Cytotoxicity of (2, 2': 6', 2''-Terpyridine) platinum (II) Complexes to Leishmania d onovani, Trypanosoma c ruzi, and Trypanosoma b rucei

…, L Tweedale, JM Pratt, P Rock, V Yardley…

Index: Lowe, Gordon; Droz, Anne Sophie; Vilaivan, Tirayut; Weaver, George W.; Tweedale, Lindsay; Pratt, Jonathan M.; Rock, Peter; Yardley, Vanessa; Croft, Simon L. Journal of Medicinal Chemistry, 1999 , vol. 42, # 6 p. 999 - 1006

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Citation Number: 113

Abstract

A range of (2, 2': 6', 2''-terpyridine) platinum (II) complexes are shown to possess antiprotozoal activity in vitro against Leishmania donovani, Trypanosoma cruzi, and Trypanosoma brucei, the causative organisms of tropical diseases leishmaniasis and trypanosomiasis. The best compounds caused 100% and 78% inhibition of growth of the intracellular amastigote forms of L. donovani and T. cruzi, respectively, at a concentration ...