European journal of medicinal chemistry

Synthesis of a new type of 'bent'heterocyclic benzimidazolo-pyridazinones

R Jonas, H Prücher, H Wurziger

Index: Jonas, R; Pruecher, H; Wurziger, H European Journal of Medicinal Chemistry, 1993 , vol. 28, # 2 p. 141 - 148

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Citation Number: 18

Abstract

Abstract The synthesis of some new heterocyclic benzimidazolo-pyridazinones starting from 2, 1, 3-benzothiadiazole-4-carboxaldehyde 2 is described. Biological evaluation of all new compounds proved them to be inhibitors of phosphodiesterase III with no marked positive inotropic effects.