Synthesis and biological activity of 2-arylaminonicotinic acid hydrazide derivatives
…, LB Falaleeva, NI Shramm, LM Polukhina…
Index: Mikhalev, A. I.; Falaleeva, L. B.; Shramm, N. I.; Polukhina, L. M.; Zalesov, V. S.; Pershin, G. N. Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 1 p. 14 - 16 Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 1 p. 36 - 39
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Abstract
By the interaction of methyl 2-(p-anisidino)-nicotinate [2] with hydrazine hydrate, the hydrazide of this acid was obtained, which during heating in alcohol with aldehydes or ketones forms the corresponding hydrazide derivatives with good yields, and forms the p- toluenesulfanil hydrazide of 2-(p-anisidino), nicotinic acid with p-toluenesulfochloride in pyridine. The thioamide (VIII) and amidrazone of 2-anilinonicotinic acid (IX) were also ...
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