Synthesis and antihyperlipidemic activity of some novel condensed 2-chloroalkyl-4-chloro/hydroxy-5, 6-disubstituted pyrimidines

MK Kathiravan, CJ Shishoo, KG Kumar…

Index: Kathiravan, Matthu K.; Shishoo, Chamanlal J.; Kumar, Krishnan Girish; Roy, Saroj Kumar; Mahadik, Kakasheb R.; Kadam, Shivajirao S.; Jain, Kishor S. Arzneimittel-Forschung/Drug Research, 2007 , vol. 57, # 9 p. 599 - 606

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Citation Number: 14

Abstract

Abstract Synthesis and antihyperlipidemic activity of a series of novel condensed 2- chloroalkyl-4-chloro/hydroxy-5, 6-di-substituted pyrimidines are described. The design of these compounds is based on the earlier QSAR study on the antihyperlipidemic 2- substituted methylthienopyrimidin-4-ones. The newly synthesized condensed 4-chloro-2- chloroalkylpyrimidines (IIIa-n) have exhibited much superior antihyperlipidemic activity, ...