Antihypertensively active amidoximes

RP Mull, P Schmidt, MR Dapero, J Higgins…

Index: Mull et al. Journal of the American Chemical Society, 1958 , vol. 80, p. 3769,3770

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Citation Number: 15

Abstract

A study of its effects on the cardiovascular system of the dog revealed that a single intravenous dose of 30 mg./kg. lowered the arterial pressure of neurogenic and renal hypertensive dogs. However, in normotensive animals 30 mg./kg. of the compound given intravenously eliminated the severe hypertension elicited by high doses of amphetamine and ephedrine and also markedly antagonized carotid occlusion reflex pressor re-