Intramolecular Friedel-Crafts reaction of 3-cyclohexen-1-acetyl chloride and its 4-methyl analog
SA Monti, GL White
Index: Monti,S.A.; White,G.L. Journal of Organic Chemistry, 1975 , vol. 40, # 2 p. 215 - 217
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Citation Number: 21
Abstract
The intramolecular Friedel-Crafts acylation of aliphatic substrates to give fused-ring products is well documented. 2, 3 This method also provides an attractive synthetic route to bicyclic derivatives characterized by differentiated functionality in two bridge^.^ An investigation of the Lewis acid catalyzed cyclization of 3-cyclohexen-1-acetyl chloride (1) and its 4-methyl analog 2 was undertaken to evaluate further this approach to functionalized bicyclooctane ...
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