Synthesis

A convenient new synthesis of a Naproxen precursor

SJ Mahmood, C Brennan, MM Hossain

Index: Mahmood, Syed J.; Brennan, Courtney; Mahmun Hossain Synthesis, 2002 , # 13 p. 1807 - 1809

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Citation Number: 8

Abstract

Abstract A precursor of Naproxen, 2-(6-methoxy-2-naphthyl) propenoic acid was synthesized in good yield from commercially available 6-methoxy-2-naphthaldehyde in three steps. The synthesis includes an unprecedented one-step reduction of acrylic acid ethyl ester to propenoic acid ethyl ester in high yield.

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