Highly Selective Metalations of Pyridines and Related Heterocycles Using New Frustrated Lewis Pairs or tmp??Zinc and tmp??Magnesium Bases with BF3⋅ OEt2

…, A Unsinn, K Karaghiosoff, P Knochel

Index: Jaric, Milica; Haag, Benjamin A.; Unsinn, Andreas; Karaghiosoff, Konstantin; Knochel, Paul Angewandte Chemie - International Edition, 2010 , vol. 49, # 32 p. 5451 - 5455

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Citation Number: 88

Abstract

The functionalization of pyridines and quinolines is a major synthetic goal since many of these heterocycles have important biological properties [1] or are of interest as new materials.[2] The regioselective functionalization of these heterocyclic scaffolds has been achieved by direct metalation [3] or metal-catalyzed CÀH activation.[4] The stoichiometric lithiation of unactivated pyridines is often complicated because of Tchitchibabin-type ...