Nitrogenous organosilicon compounds. CX. Synthesis and pharmacological study of organosilicon aminoalcohols and their derivatives

…, MM Veveris, ZA Atare, ID Segal, LN Khokhlova…

Index: Lukevits, E.; Veveris, M. M.; Atare, Z. A.; Segal, I. D.; Khokhlova, L. N.; Kimenis, A. A. Pharmaceutical Chemistry Journal, 1982 , vol. 16, # 10 p. 764 - 768 Khimiko-Farmatsevticheskii Zhurnal, 1982 , vol. 16, # 10 p. 1204 - 1209

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Abstract

The curariform and ganglion-blocking activity of the compounds were studied, together with their effects on the blood circulatory system and modification of the effects of biogenic amines. Acute toxicities were also determined. The pharmacological studies showed that in experiments with narcotized cats, several of the compounds showed curariform activity when administered by the intravenous route (Table 3), but the doses were relatively high, and ...