Formation of nitrogen??containing heterocycles using di (imidazole??1??yl) methanimine

YQ Wu, DC Limburg, DE Wilkinson…

Index: Wu, Yong-Qian; Limburg, David C.; Wilkinson, Douglas E.; Hamilton, Gregory S. Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 1 p. 191 - 193

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Citation Number: 25

Abstract

Many natural products and synthetic pharmaceuticals contain heterocyclic groups, which often play an essential role in their biological activity [1]. Cyanogen halides have been widely used in the preparation of nitrogen- containing heterocycles via a double attack by the nitrogen and another heteroatom nucleophile (eg O, S, N); how- ever they suffer many drawbacks, including high volatility and high toxicity [2]. In addition, cyanogen bromide reacts readily with ...