Regioselective Alkylation of 2-Alkyl-5, 6, 7, 8-tetrahydro-3H-cycloheptimidazol-4-ones and 2-Alkyl-3H-cycloheptimidazol-4-ones
M Sonegawa, M Yokota, H Tomiyama…
Index: Sonegawa, Motoharu; Yokota, Masayuki; Tomiyama, Hiroshi; Tomiyama, Tsuyoshi Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 5 p. 706 - 710
Full Text: HTML
Citation Number: 13
Abstract
Regioselective alkylation of 2-alkyl-5, 6, 7, 8-tetrahydro-3H-cycloheptimidazol-4-one (1) and 2-alkyl-3H-cycloheptimidazol-4-one (2) was investigated. 3-[2′-(1-tert-Butyl-1H-tetrazol-5- yl) biphenyl-4-ylmethyl]-2-propyl-5, 6, 7, 8-tetrahydro-1H-cycloheptimidazol-4-one (6) was preferentially obtained under the conditions by using NaH in DMF or THF. On the other hand, 3-[2′-(1-tert-butyl-1H-tetrazol-5-yl) biphenyl-4-ylmethyl]-2-propyl-5, 6, 7, 8- ...
Related Articles:
[Maatougui, Abdelaziz El; Crespo, Abel; Silva, Artur M.S.; Coelho, Alberto Combinatorial Chemistry and High Throughput Screening, 2011 , vol. 14, # 7 p. 570 - 582]
Synthesis of N1-Aryl-and N1-Benzyl Substituted Imidazole-4-and Imidazole-5-carbaldehydes
[Antonini, Ippolito; Cristalli, Gloria; Franchetti, Palmarisa; Grifantini, Mario; Martelli, Sante Synthesis, 1983 , # 1 p. 47 - 49]
[Oresmaa, Larisa; Taberman, Helena; Haukka, Matti; Vainiotalo, Pirjo; Aulaskari, Paula Journal of Heterocyclic Chemistry, 2007 , vol. 44, # 6 p. 1445 - 1451]