Bioorganic & medicinal chemistry

Regulatory molecules for the 5-HT 3 receptor ion channel gating system

S Yoshida, T Watanabe, Y Sato

Index: Yoshida, Satoshi; Watanabe, Takashi; Sato, Yasuo Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 10 p. 3515 - 3523

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Citation Number: 37

Abstract

Substituted benzoxazole derivatives which possess a nitrogen-containing heterocycle at C2 are selective partial agonists of the 5-HT3 receptor. Alteration of substituents on the benzoxazole nucleus affords both agonist-like and antagonist-like compounds, and uniquely modifies the function of the 5-HT3 receptor ion channel gating system. SAR and corroborative computational docking study for these partial agonists successfully ...