Synthesis of new N, N′-bis [1-aryl-3-(piperidine-1-yl) propylidene] hydrazine dihydrochlorides and evaluation of their cytotoxicity against human hepatoma and …

K Kucukoglu, HI Gul, R Cetin-Atalay…

Index: Kucukoglu, Kaan; Gul, H. Inci; Cetin-Atalay, Rengul; Baratli, Yosra; Charles, Anne-Laure; Sukuroglu, Murat; Gul, Mustafa; Geny, Bernard Journal of Enzyme Inhibition and Medicinal Chemistry, 2014 , vol. 29, # 3 p. 420 - 426

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Citation Number: 6

Abstract

Abstract N, N′-Bis [1-aryl-3-(piperidine-1-yl) propylidene] hydrazine dihydrochlorides were synthesized by the reaction of 2 mols of 1-aryl-3-(piperidine-1-yl)-1-propanone hydrochlorides with 1 mol of hydrazine hydrate. Aryl part was C6H5 (P1), 4-CH3C6H4 (P2), 4-CH3OC6H4 (P3), 4-HOC6H4 (P4), 4-ClC6H4 (P5), 3-CH3OC6H4 (P6), 4-FC6H4 (P7) and 4-BrC6H4 (P8). Except P1, all compounds were reported for the first time. The chemical ...