Synthesis of novel macrolide derivatives with imidazo [4, 5-b] pyridinyl sulfur contained alkyl side chains and their antibacterial activity

P Xu, L Liu, X Chen, Y Li, J Liu, Z Jin, G Wang…

Index: Xu, Peng; Liu, Lu; Chen, Xiao-zhuo; Li, Yun; Liu, Jian; Jin, Zhi-ping; Wang, Guang-qiang; Lei, Ping-sheng Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4079 - 4083

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Citation Number: 10

Abstract

In an effort to find new antibiotics, a novel series of 14-membered macrolides with imidazo [4, 5-b] pyridinyl sulfur contained alkyl side chains has been synthesized based on commercially available clarithromycin. Chemical transformation of hydroxy group at position C-3 afforded range of ketolides and acylides. Compared to telithromycin, compound 15a demonstrated improved in vitro activity against erythromycin-susceptible and-resistant ...